Abstract #3025

ADC-corrected SUV derived from voxel-based SUV-ADC scatter plots for the evaluation of soft-tissue tumor treatment response in FDG-PET/MR hybrid imaging

Sungtak Hong¹, Yuji Watanabe², Daiki Shinyama¹, Keisuke Ishimatsu³, Koji Sagiyama³, and Hiroshi Honda³

¹Philips Japan, Tokyo, Japan, ²Department of Molecular Imaging and Diagnosis, Kyushu University, Fukuoka, Japan, ³Department of Clinical Radiology, Kyushu University, Fukuoka, Japan

It is often difficult to quantify tumor treatment response with SUVmax because a single voxel measurement does not always represent a whole tumor. In this study, we developed a new parameter called cellular SUV (cSUV) from the SUV-ADC scatter plots. Cluster analysis also applied to the cSUV-measurement of a tumor consisting of multiple components such as liposarcoma, necrotic tumor after treatment, etc. The percent change in cSUV between pre- and post-treatment correlated better with the RECIST1.0 assessment than that of SUVmax. The cSUV combined with cluster analysis could be a promising bio-imaging marker for monitoring treatment response of soft-tissue tumors.

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