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Abstract #3025

ADC-corrected SUV derived from voxel-based SUV-ADC scatter plots for the evaluation of soft-tissue tumor treatment response in FDG-PET/MR hybrid imaging

Sungtak Hong1, Yuji Watanabe2, Daiki Shinyama1, Keisuke Ishimatsu3, Koji Sagiyama3, and Hiroshi Honda3

1Philips Japan, Tokyo, Japan, 2Department of Molecular Imaging and Diagnosis, Kyushu University, Fukuoka, Japan, 3Department of Clinical Radiology, Kyushu University, Fukuoka, Japan

It is often difficult to quantify tumor treatment response with SUVmax because a single voxel measurement does not always represent a whole tumor. In this study, we developed a new parameter called cellular SUV (cSUV) from the SUV-ADC scatter plots. Cluster analysis also applied to the cSUV-measurement of a tumor consisting of multiple components such as liposarcoma, necrotic tumor after treatment, etc. The percent change in cSUV between pre- and post-treatment correlated better with the RECIST1.0 assessment than that of SUVmax. The cSUV combined with cluster analysis could be a promising bio-imaging marker for monitoring treatment response of soft-tissue tumors.

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