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Abstract #3028

Truly simultaneous preclinical PET-MRI in a 20cm 9.4 Tesla magnet with a retrofitted miniature detector: Initial results in the twitcher mouse model of Krabbe disease

Ferdinand Schweser1,2, Akshay V Dhamankar1, Poonam Choudhary1,3, Nadav Weinstock4,5, Cheryl Knapp2, Marilena Preda1,2, Daesung Shin4,5, Robert Zivadinov1,2, and Lawrence Wrabetz4,5,6

1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 2Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States, 3Department of Medical Physics, University at Buffalo, The State University of New York, Buffalo, NY, United States, 4Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 5Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 6Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States

While the potential of PET-MRI is increasingly being explored in the clinical setting, preclinical PET-MRI is only slowly leaving the proof-of-concept stage, which may be explained by technical difficulties due to the size-constraints and strong magnetic fields used in preclinical MRI. In the current work, we present results from a first in vivo application of 18F-FDG PET-MRI using a retrofitted micro-PET detector in a commercial 9.4T magnet. We studied the twitcher mouse model of Krabbe disease, in which an altered glucose metabolism had been suggested.

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