Abstract #3072

Hyperpolarized 13C chemical shift imaging of transient focal ischemia reperfusion injury in developing rat brain

Shu-Juan Fan¹, Amara Larpthaveesarp², Yiran Chen^1,3, Sukumar Subramaniam¹, Robert Bok¹, Fernando Gonzalez², and Duan Xu¹

¹Dept. of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Dept. of Pediatrics, University of California San Francisco, San Francisco, CA, United States, ³Joint UCSF/UC Berkeley Graduate Group in Bioengineering, San Francisco, CA, United States

We investigated the use of hyperpolarized [1-¹³C]pyruvate magnetic resonance chemical shift imaging in monitoring energy metabolism in developing rat brain following transient focal ischemia-reperfusion injury, which is the most common form of stroke in neonates. We show that the conversion from [1-¹³C]pyruvate to [1-¹³C]lactate was higher in the injured cerebral hemisphere as compared with that in the contralateral hemisphere, which lasted for up to 7 days after the ischemia-reperfusion injury. This phenomenon can be potentially used as a biomarker to facilitate long-term prognosis, characterize therapeutic responses and study the mechanisms of injury repair in neonates with transient focal ischemic stroke.

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