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Abstract #3072

Hyperpolarized 13C chemical shift imaging of transient focal ischemia reperfusion injury in developing rat brain

Shu-Juan Fan1, Amara Larpthaveesarp2, Yiran Chen1,3, Sukumar Subramaniam1, Robert Bok1, Fernando Gonzalez2, and Duan Xu1

1Dept. of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Dept. of Pediatrics, University of California San Francisco, San Francisco, CA, United States, 3Joint UCSF/UC Berkeley Graduate Group in Bioengineering, San Francisco, CA, United States

We investigated the use of hyperpolarized [1-13C]pyruvate magnetic resonance chemical shift imaging in monitoring energy metabolism in developing rat brain following transient focal ischemia-reperfusion injury, which is the most common form of stroke in neonates. We show that the conversion from [1-13C]pyruvate to [1-13C]lactate was higher in the injured cerebral hemisphere as compared with that in the contralateral hemisphere, which lasted for up to 7 days after the ischemia-reperfusion injury. This phenomenon can be potentially used as a biomarker to facilitate long-term prognosis, characterize therapeutic responses and study the mechanisms of injury repair in neonates with transient focal ischemic stroke.

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