Abstract #3075

2-year-old human brain DTI atlas with comprehensive gray and white matter labels

Limei Song^1,2, Yun Peng³, Qinmu Peng², Lei Feng¹, Minhui Ouyang², Huiying Kang³, Shuwei Liu¹, and Hao Huang^2,4

¹Shandong University School of Medicine, Jinan, China, ²The Children’s Hospital of Philadelphia, Philadelphia, PA, United States, ³Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing, China, ⁴Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

2-year-old, marking the end of infancy, is critical for understanding not only precisely organized normal brain development but also serving as clinical anatomical references for neurodevelopmental disorders such as autism. The 2-year-old brain labels transformed from adult atlases lead to relatively large offsets due to dramatic and nonlinear neuroanatomical differences of the brains between these two populations. With DTI data from nineteen healthy 2-year-old subjects, we created a 2-year-old brain DTI atlas with comprehensive labels of 124 gray and white matter structures. The test results suggested the established atlas can be applied to label 2-year-old brain images automatically and accurately.

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