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Abstract #3082

Thalamic nuclei segmentation on dementia using tractography and population-specific priors

Carla Semedo1, M. Jorge Cardoso1,2, S. B. Vos1,3,4, Carole H. Sudre1,2, Martina Bocchetta2, Annemie Ribbens5, Dirk Smeets5, Jonathan Rohrer2, and Sebastien Ourselin1,2

1Translational Imaging Group, UCL, London, United Kingdom, 2Dementia Research Centre, UCL, London, United Kingdom, 3MRI Unit, Epilepsy Society, Chalfont St Peter, United Kingdom, 4Wellcome EPSRC Centre for Interventional and Surgical Sciences (WEISS), UCL, London, United Kingdom, 5Icometrix, Leuven, Belgium

Thalamic changes have been reported in several neurological disorders, such as Alzheimer's disease and frontotemporal dementia (FTD). As pathologies affect different cortical and subcortical brain regions disproportionally, accurate segmentation of thalamic nuclei can provide relevant insights about brain function and neurological disorders mechanisms. Here, we used a previously developed thalamus parcellation strategy that relies on tractography and population-specific to infer any connectivity changes in presence of FTD. The obtained results were compared against to the ones derived with the commonly used probabilistic tractography pipeline available in FSL.

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