Meeting Banner
Abstract #3090

Looking at the structural connectivity of the frontal inferior cortex to better decipher the inhibitory control mechanisms in Obsessive Compulsive Disorder

Ivy Uszynski1,2, Cyril Poupon2, Cédric Pichat3,4, Pauline Favre2, Benjamin Fredembach3, Hervé Mathieu1,5,6,7, Laurent Lamalle6,7, Alexandre Krainik1,6,7, Olivier David1,5, Emmanuel L. Barbier1,5, and Mircea Polosan1,5,8

1Grenoble Institut des Neurosciences, Université Grenoble Alpes, Grenoble, France, 2NeuroSpin, CEA Saclay, Gif-sur-Yvette, France, 3Department of Psychology, Université Grenoble Alpes, Grenoble, France, 4LPNC UMR 5105, CNRS, Grenoble, France, 5INSERM U1216, Grenoble, France, 6Unité Mixte de Service IRMaGe, CHU Grenoble Alpes, Grenoble, France, 7Unité Mixte de Service 3552, CNRS, Grenoble, France, 8Department of Psychiatry, CHU Grenoble Alpes, Grenoble, France

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disease affecting 2.5-3% of the population and characterized by repetitive compulsive behaviours with severe complications such as depression, suicide and addiction. Diffusion MRI is a powerful non-invasive technique that evaluates the integrity of the white matter pathways such as those implicated in the impulse control, likely to be impaired in OCD. Here, we investigate the connectivity of the right posterior inferior frontal cortex and in particular to the presupplementary motor area (also involved in inhibition), to the striatum (involved in proactive and/or selective control) and to the primary motor cortex in the contralateral hemisphere.

This abstract and the presentation materials are available to members only; a login is required.

Join Here