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Abstract #3092

Diffusion MRI as an imaging marker of depression from a large and homogenous population study

Julie Coloigner1, Jean-Marie Batail1,2,3, Isabelle Corouge1, Jean-Christophe Ferré1,4, Dominique Drapier2,5, and Christian Barillot1

1Univ Rennes, Inria, CNRS, Inserm, IRISA UMR 6074, VISAGES ERL U-1228, F-35000, Rennes, France, 2Academic Psychiatry Department, Centre Hospitalier Guillaume Régnier, Rennes, France, 3EA 4712 Behavior and Basal Ganglia, CHU Rennes, Rennes 1 University, Rennes, France, Metropolitan, 4Department of Neuroradiology, University Hospital of Rennes, Rennes, France, 52 EA 4712 Behavior and Basal Ganglia, CHU Rennes, Rennes, France

Despite the extensive therapy options available for depression, up to 80% of patients will suffer from a relapse. Consequently, understanding the neural correlates underlying the depression will optimize the diagnosis and treatment of individual depressed patients. The purpose of our study was to investigate alterations of white matter integrity in a large cohort of patients suffering from depression using diffusion tensor imaging. Our findings provide robust evidence that the reduction of white-matter integrity in the interhemispheric connections and fronto-limbic neuronal circuits may play an important role in depression pathogenesis.

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