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Abstract #3104

MRI approaches to map focal cortical dysplasia in focal epilepsy using anomalous diffusion and magnetic susceptibility

Qiang Yu1, David Reutens1, Javier Urriola1, Surabhi Sood1, and Viktor Vegh1

1Centre for Advanced Imaging, University of Queensland, Brisbane, Australia

Focal cortical dysplasias (FCD) are developmental malformations of the cerebral cortex that are often highly epileptogenic. When medications fail to control seizures, surgical removal of dysplastic epileptogenic tissue may be curative. But, in 20-­40% of patients current MRI scans cannot identify FCD affected brain regions. Building on the anomalous nature of diffusion and magnetic susceptibility of tissue, we aimed to improve in vivo identification of FCD in the brain. We found the combination of anomalous diffusion model parameters and tissue magnetic susceptibility can be used to differentiate FCD from healthy tissue in the brain.

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