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Abstract #3115

Towards the assessment of myelination using time-dependent diffusion MRI indices.

Abib O. Y. Alimi1, Alexandra Petiet2, Mathieu Santin2, Anne-Charlotte Philippe2, Stephane Lehericy2,3, Rachid Deriche1, and Demian Wassermann1,4

1Université Côte d'Azur, Inria, Valbonne, France, 2Institut du Cerveau et de la Moelle épinière – ICM, Centre de NeuroImagerie de Recherche – CENIR, Paris, France, 3Sorbonne Universités, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, Paris, France, 4Inria, CEA, Université Paris-Saclay, Paris, France

We study the sensitivity of time-dependent diffusion MRI indices or qτ-indices to demyelination in the mouse brain. For this, we acquire in vivo four-dimentional diffusion-weighted images -varying over gradient strength, direction and diffusion time- and estimate the qτ-indices from the corpus callosum. First order Taylor approximation of each index gives fitting coefficients α and β whose variance we investigate. Results indicate that, cuprizone intoxication affects mainly index coefficient β by introducing inequality of variances between the two mice groups, most significantly in the splenium and that MSD increases and RTOP decreases over diffusion time τ.

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