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Abstract #3122

Diffusion MRI in muscles at high b-values: towards a quantification of microscopic organelles

Nicolas Moutal1, Denis Grebenkov1, Sylvie Clerjon2, Guilhem Pages2, and Jean-Marie Bonny2

1PMC, CNRS – Ecole Polytechnique, F-91128, Palaiseau, France, 2AgroResonance - UR370 QuaPA, F-63122, Saint Genès Champanelle, France

We present an application of diffusion MRI at high b-values to a non-invasive quantification of micron-sized organelles such as mitochondria. The experiments were conducted ex vivo on pork muscle and analyzed with a bi-exponential tensorial model, which allows us to estimate the mitochondria content in the muscle. Even though a more systematic comparison between mesoscale diffusion and microscale histology is deserved, this work is a proof of concept and a prerequisite for developing in vivo methods for quantifying the content of various organelles in muscles, e.g. for studying mitochondrial dysfunction in aging.

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