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Abstract #3145

Evaluation of errors in image registration and diffusion measurement due to the cavum septum pellucidum

Chen-Hsiang Weng1, Yung-Chin Hsu1, and Wen-Yih Isaac Tseng1,2

1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 2Molecular Imaging Center, National Taiwan University, Taipei, Taiwan, Taipei, Taiwan

To determine the registration errors caused by the cavum septum pellucidum (CSP), Dice coefficient and generalized fractional anisotropy (GFA) were assessed in brain using T1-weighted imaging and diffusion spectrum imaging (DSI), respectively. The subjects included 30 subjects with the CSP and 30 subjects without the CSP. Comparing with the subjects without the CSP, the subjects who had enlarged CSP showed significantly decreased Dice coefficient and significantly different GFA values in nine tracts. Our findings indicate that the existence of the CSP leads to errors in image registration and diffusion index calculation, and that the size of the CSP should be taken into consideration as a covariate in statistical analysis.

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