Abstract #3149

On Resonance Variable Delay Multiple Pulse (onVDMP) CEST MRI Detects Transient Lactate Depletion during Experimental Autoimmune Encephalomyelitis Progression

Aline Thomas¹, Jiadi Xu², Peter Calabresi³, Peter van Zijl², and Jeff Bulte¹

¹Radiology, Johns Hopkins School of Medicine, Baltimore, MD, United States, ²Radiology, Kennedy Krieger Institute, Baltimore, MD, United States, ³Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States

On resonance variable delay multiple pulse CEST MRI detected a transient reduction in lactate levels in the cerebrospinal fluid during the disease course of a mouse model of multiple sclerosis, which was validated using magnetic resonance spectroscopy.

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