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Abstract #3161

Brain stiffness changes due to Alzheimer’s disease in cortical-centric regions

Matthew Christopher Murphy1, David T Jones1, Clifford C Jack1, Kevin C Glaser1, Matthew C Senjem1, Armando C Manduca1, Joel C Felmlee1, Richard C Ehman1, and John C Huston1

1Mayo Clinic, ROCHESTER, MN, United States

Brain stiffness is known to decrease in subjects with Alzheimer’s disease (AD). However, previously reported stiffness estimates were heavily weighted toward white matter. Here we investigate the sensitivity of cortical-centric stiffness measurements for detecting AD pathophysiology, given that the cortex is the primary site of pathology. Using a neural network-based inversion algorithm, cortical-centric measurements are highly repeatable with test-retest errors of less than 2% on average. With respect to AD, the medial temporal lobe region of interest is found to best discriminate those with dementia from cognitively normal subjects, and performs better than previously reported methods.

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