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Abstract #3163

Assessment of cerebral infarction due to intracranial arterial stenosisĀ in the human brain using hyperpolarized xenon-129 MRI

Madhwesha Rao1, Graham Norquay1, Neil J Stewart1, Nigel Hoggard1, Paul D Griffiths1, and Jim M Wild1

1University Of Sheffield, Sheffield, United Kingdom

In this pilot study we evaluate the feasibility of hyperpolarised 129Xe brain perfusion MR imaging to evaluate brain tissue perfusion patho-physiology in a subject with established intracranial arterial stenosis with collateralized blood flow. The 129Xe brain perfusion images from the patient exhibit regions of signal void which correspond to the infarcted region observed on T2 weighted MRI. Imaging hyperpolarized 129Xe dissolved in the brain tissue is a direct method of imaging perfusion of the tissue itself and we observe different patterns of cerebral perfusion than those measured with arterial spin labeling.

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