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Abstract #3170

Novel Imaging Phantom for Accurate and Robust Measurement of Brain Atrophy Rates Using Clinical MRI

Houshang Amiri1, Iman Brouwer1, Joost P.A. Kuijer1, Jan C. de Munck1, Frederik Barkhof1,2, and Hugo Vrenken1

1Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands, 2Institutes of Neurology and Healthcare Engineering, UCL, London, United Kingdom

MR images are widely used to measure brain atrophy in neurodegenerative diseases. However, reliable evaluation of atrophy is hampered by scanner-induced systematic variability. Here, we developed an MR-compatible phantom and analysis software for robust and reliable evaluation of the brain volume loss. The phantom was made using 3D-printing and contains three inflatable brain structures equipped with a precise volume change system. The phantom was imaged at three different clinical 3T MR scanners and images were analyzed by our developed software. This phantom can accurately and robustly provide a selected volume change to mimic a certain disease.

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