Abstract #3187

Rapid Myelin Measurement: Comparison Between SyMRI (Simultaneous Tissue Relaxometry), Magnetization Transfer Saturation Index, and T1w/T2w Ratio Methods

Akifumi Hagiwara^1,2, Masaaki Hori², Koji Kamagata², Misaki Nakazawa², Christina Andica², Tomoko Maekawa^1,2, Saori Koshino^1,2, Ryusuke Irie^1,2, Lydia Chougar^2,3, Osamu Abe¹, and Shigeki Aoki²

¹Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan, ³Hôpital Cochin, Paris, France

In 20 healthy adults, we examined the correlation between three rapid MR myelin measurement methods, including simultaneous tissue relaxometry of R1 and R2 relaxation rates and proton density (SyMRI), magnetization transfer saturation (MTsat) index, and the ratio of T1-weighted to T2-weighted images (T1w/T2w ratio). Even though SyMRI and MTsat showed strong correlation in the white matter, only weak to moderate correlation was found between T1w/T2w and SyMRI or MTsat. In conclusion, SyMRI and MTsat seem to be suitable for evaluating myelin in the white matter, but T1w/T2w ratio may be less optimal.

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