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Abstract #3187

Rapid Myelin Measurement: Comparison Between SyMRI (Simultaneous Tissue Relaxometry), Magnetization Transfer Saturation Index, and T1w/T2w Ratio Methods

Akifumi Hagiwara1,2, Masaaki Hori2, Koji Kamagata2, Misaki Nakazawa2, Christina Andica2, Tomoko Maekawa1,2, Saori Koshino1,2, Ryusuke Irie1,2, Lydia Chougar2,3, Osamu Abe1, and Shigeki Aoki2

1Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan, 3Hôpital Cochin, Paris, France

In 20 healthy adults, we examined the correlation between three rapid MR myelin measurement methods, including simultaneous tissue relaxometry of R1 and R2 relaxation rates and proton density (SyMRI), magnetization transfer saturation (MTsat) index, and the ratio of T1-weighted to T2-weighted images (T1w/T2w ratio). Even though SyMRI and MTsat showed strong correlation in the white matter, only weak to moderate correlation was found between T1w/T2w and SyMRI or MTsat. In conclusion, SyMRI and MTsat seem to be suitable for evaluating myelin in the white matter, but T1w/T2w ratio may be less optimal.

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