Diffusion kurtosis imaging (DKI) is a recently developed diffusion model that measures the non-Gaussian diffusion of water molecules in biological tissue. Few studies reported the potential of DKI on assessing hepatic fibrosis. Aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (FIB-4) are widely used non-invasive serum tests that estimate liver fibrosis. We compared the diagnostic performance of DKI, conventional DWI, APRI, and FIB-4 for evaluating the severity of liver fibrosis. Our results showed that diffusion-based measurements offer a similar diagnostic performance to the serum fibrosis biomarkers APRI and FIB-4 index for predicting liver fibrosis in patients with chronic liver disease.