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Abstract #3203

Assessment of Liver Fibrosis: Comparison of Diffusion Kurtosis Imaging, Conventional DWI, Aspartate Aminotransferase-to-Platelet Ratio Index and Fibrosis-4

Li Yang1, Mengsu Zeng1, Shengxiang Rao1, Caizhong Chen1, Robert Grimm2, Caixia Fu3, and Xu Yan4

1Zhongshan Hospital, Fudan University, Shanghai, China, 2MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany, 3Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, 4MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China

Diffusion kurtosis imaging (DKI) is a recently developed diffusion model that measures the non-Gaussian diffusion of water molecules in biological tissue. Few studies reported the potential of DKI on assessing hepatic fibrosis. Aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (FIB-4) are widely used non-invasive serum tests that estimate liver fibrosis. We compared the diagnostic performance of DKI, conventional DWI, APRI, and FIB-4 for evaluating the severity of liver fibrosis. Our results showed that diffusion-based measurements offer a similar diagnostic performance to the serum fibrosis biomarkers APRI and FIB-4 index for predicting liver fibrosis in patients with chronic liver disease.

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