Abstract #3206

Prostate Cancer: Influence of the Diffusion Time on Diffusion Kurtosis Imaging

Tristan Anselm Kuder¹, Frederik Bernd Laun², David Bonekamp³, and Matthias Carl Röthke^3,4

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ³Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁴Conradia, Hamburg, Germany

Diffusion MRI is routinely used in prostate cancer diagnosis. Diffusion kurtosis imaging allows measuring the kurtosis K_app, related to deviations from free diffusion, additionally to the diffusion coefficient D_app. Varying the diffusion time may yield additional information about the investigated tissue by probing the diffusion barriers at different length scales. Here, D_app and K_app were measured at three diffusion times in 27 patients with histologically confirmed prostate cancer. A reduction of K_app was observed in tumor and normal control regions with increasing diffusion time, while a D_app reduction was mostly seen in control regions.

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