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Abstract #3219

How do current diffusion-based MR methods reflect hypomyelination – comparison of diffusion tensor, neurite orientation dispersion and density, and diffusion kurtosis imaging

Rakshit Dadarwal1, Amir Moussavi1, Wiebke Möbius2, and Susann Boretius1

1Functional Imaging Laboratory, German Primate Center, Göttingen, Germany, 2Department of Neurogenetics, Max Planck Institute for Experimental Medicine, Göttingen, Germany

Diffusion-based MRI comprises an exciting toolset to analyze tissue microstructures under normal and pathological conditions. Among numerous diffusion-based methods compared, all reflected the differences in myelination in a mouse model expressing only reduced levels of the myelin basic protein. However, diffusion tensor was more robust than diffusion kurtosis imaging. Intra-neurite volumes, as revealed by neurite orientation dispersion and density imaging or by the spherical mean technique, were not specific for the numbers of axons but were also affected by difference in myelination.

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