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Abstract #3225

Design of multi-purpose and 3D-printed fibre phantoms for investigating complex tissue microstructures

Husan-Han Chiang1, Kuan-Hung Cho1, Ezequiel Farrher2, Johannes Lindemeyer2, Richard Buschbeck2, Ming-Jye Chen1, Farida Grinberg2,3, Nadim Jon Shah2,3, Chang-Hoon Choi2, and Li-Wei Kuo1

1Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, 2Institute of Neuroscience and Medicine – 4, Forschungszentrum Juelich, Juelich, Germany, 3Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany

Investigating complex tissue microstructures has become of great interest during the past decade. One of the most promising MRI methods to map tissue microstructures is diffusion MRI. However, the validation of its accuracy in mapping fibre orientation and microstructural characteristics is still challenging. In this work, we have successfully designed and prototyped a fibre phantom using 3D printing and micro-scale fused silica capillaries. Our results show that susceptibility of the capillaries and/or the coating material is different from that of distilled water and suggest that our phantom design could provide detectable microstructures for further studies.

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