Abstract #3227

MR Characterization and Temperature Dependence of Aqueous Polyvinylpyrolidone (PVP) Solutions for use as MR Phantoms

Joelle E Sarlls¹, Michal Komlosh², Ferenc Horkay², Uri Nevo³, Peter J Basser², and Carlo Pierpaoli⁴

¹NINDS/NMRF, National Institutes of Health, Bethesda, MD, United States, ²NICHD, National Institutes of Health, Bethesda, MD, United States, ³Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, ⁴NIBIB, National Institutes of Health, Bethesda, MD, United States

Diffusion-weighted MRI methods often contain variability and bias in diffusion parameters that are measured between sites, scanners, and vendors. There is a clear need for a calibrated diffusion phantom to help identify and mitigate these differences. Here we utilize a 7T spectrometer to characterize MR parameters of T₁, T₂, and the water self-diffusion coefficient in aqueous Polyvinylpyrolidone (PVP) solutions and their dependence on temperature and PVP concentration, without imaging confounds. An empirical formula is presented for use wtih PVP aqueous solutions as a calibrated diffusion phantom. Data show that aqueous PVP solutions are well suited as a MR phantom material.

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