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Abstract #3234

Histological breast cancer stroma patterns correlate with diffusion MR signal

Sara Reis1, Colleen Bailey1, Thomy Mertzanidou1, Bernard Siow2, Eleftheria Panagiotaki1, John H. Hipwell1, Julie Owen3, Patrycja Gazinska3, Sarah E. Pinder3, Daniel C. Alexander1, and David J. Hawkes1

1Centre for Medical Image and Computing, University College London, London, United Kingdom, 2Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 3King's College London, London, United Kingdom

We report on the histological analysis of the stroma compartment of two formalin-fixed breast cancer ex-vivo samples that were scanned under a wide range of PGSE acquisitions. Our histological analysis of stroma approach shows that mature regions present higher ADC values compared to immature regions. Mature regions are mainly composed by highly organised fibres, normally following the same direction, which may facilitate directional movement of molecules. This increases the effective tortuosity in the tumour and its interstitial fluid pressure and osmotic pressure, which inhibits water diffusion and subsequently results in a lower ADC value.

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