Abstract #3238

Reliability of Neurite Orientation Dispersion and Density Imaging (NODDI) at 9.4 Tesla

Patrick McCunn^1,2, Alex Li¹, Peter Zeman¹, Kyle Gilbert¹, Ali Khan^1,2, and Robert Bartha^1,2

¹CFMM, Robarts Research Institute, London, ON, Canada, ²Medical Biophysics, Western University, London, ON, Canada

Neurite Orientation Dispersion and Density Imaging (NODDI) is a rapidly emerging diffusion MRI (dMRI) technique used to characterize microstructural complexity through the compartmental modelling of neural water fractions into Intra-neurite, Extra-neurite and CSF volume fractions. This project aimed to further the ability of preclinical diffusion imaging through the application of NODDI to a rodent model with the objective to determine its utility, precision and reliability at 9.4 Tesla.

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