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Abstract #3238

Reliability of Neurite Orientation Dispersion and Density Imaging (NODDI) at 9.4 Tesla

Patrick McCunn1,2, Alex Li1, Peter Zeman1, Kyle Gilbert1, Ali Khan1,2, and Robert Bartha1,2

1CFMM, Robarts Research Institute, London, ON, Canada, 2Medical Biophysics, Western University, London, ON, Canada

Neurite Orientation Dispersion and Density Imaging (NODDI) is a rapidly emerging diffusion MRI (dMRI) technique used to characterize microstructural complexity through the compartmental modelling of neural water fractions into Intra-neurite, Extra-neurite and CSF volume fractions. This project aimed to further the ability of preclinical diffusion imaging through the application of NODDI to a rodent model with the objective to determine its utility, precision and reliability at 9.4 Tesla.

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