Abstract #3247

Multicentric test-retest reproducibility of human hippocampal volumes: FreeSurfer 6.0 longitudinal stream applied to 3D T1, 3D FLAIR and high-resolution 2D T2 structural neuroimaging

Andrea Chiappiniello¹, Roberto Tarducci², Cristina Muscio³, Giovanni B. Frisoni^4,5, Maria Grazia Bruzzone⁶, Marco Bozzali⁷, Daniela Perani^8,9, Pietro Tiraboschi³, Anna Nigri⁶, Claudia Ambrosi¹⁰, Massimo Caulo^11,12, Elena Chipi¹³, Stefano Chiti¹⁴, Enrico Fainardi¹⁵, Stefania Ferraro⁶, Cristina Festari^4,16, Roberto Gasparotti¹⁷, Andrea Ginestroni¹⁵, Giovanni Giulietti⁷, Lorella Mascaro¹⁸, Riccardo Navarra^11,12, Valentina Nicolosi⁴, Lucilla Parnetti¹³, Cristina Rosazza⁶, Laura Serra⁷, Fabrizio Tagliavini^3,19, and Jorge Jovicich²⁰

¹Physics and Geology Department, University of Perugia, Perugia, Italy, ²Medical Physics Department, Santa Maria della Misericordia Hospital, Perugia, Italy, ³Division of Neurology V/Neuropathology, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy, ⁴Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Fatebenefratelli, Brescia, Italy, ⁵Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland, ⁶Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy, ⁷Neuroimaging laboratory, IRCCS Santa Lucia Foundation, Rome, Italy, ⁸Vita-Salute San Raffaele University, Milan, Italy, ⁹Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy, ¹⁰University of Brescia, Brescia, Italy, ¹¹Department of Neuroscience, Imaging and Clinical Sciences, University “G. d’Annunzio” of Chieti, Chieti, Italy, ¹²Institute for Advanced Biomedical Technologies (ITAB), University “G. d’Annunzio” of Chieti, Chieti, Italy, ¹³Centre for Memory Disturbances, Lab of Clinical Neurochemistry, University of Perugia, Perugia, Italy, ¹⁴Department of Health Professions - U.O.c Research and Development, Careggi University Hospital, Florence, Italy, ¹⁵Department of Neuroradiology, Careggi University Hospital, Florence, Italy, ¹⁶Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy, ¹⁷Neuroradiology Unit, University of Brescia, Brescia, Italy, ¹⁸Medical Physics Unit, Spedali Civili di Brescia, Brescia, Italy, ¹⁹Scientific Direction, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy, ²⁰CIMEC - Center for Mind/Brain Sciences, University of Trento, Trento, Italy

This study evaluates across-session test-retest reproducibility of automatic hippocampus subfields segmentation. A customized acquisition protocol was designed to enhance segmentation reliability in FreeSurfer 6.0 longitudinal analysis stream. Images were processed performing a within-session T1 averaging, using FLAIR images for PIAL surface reconstruction and a high-resolution T2 for the hippocampal subfield segmentation. Results on 12 healthy subjects suggest high reproducibility for different hippocampal subfields and whole hippocampus, generally better than those achievable without T1 averaging and without using FLAIR and high-resolution T2 images.

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