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Abstract #3254

In-vivo probabilistic structural atlas of the inferior colliculus, superior colliculus, medial geniculate nucleus, and lateral geniculate nucleus based on 7 Tesla MRI

Christian Strong1, Nicola Toschi2,3, Bruce Rosen2, Lawrence L Wald2, and Marta Bianciardi2

1Department of Neurosurgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States, 2Department of Radiology, A.A. Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Boston, MA, United States, 3Medical Physics Section, Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome “Tor Vergata”, Rome, Italy

Brainstem and thalamic nuclei such as the inferior-colliculus, superior-colliculus, lateral-geniculate-nucleus, and medial-geniculate-nucleus modulate visual/oculo-motor and auditory/auditory-motor functions. Dysfunction of these nuclei is implicated in disease states such as auditory-agnosia, pure-word deafness, eye-movement and visual-field deficits, Parkinson’s hallucinations, and glaucoma. However, a stereotaxic probabilistic atlas of these nuclei in humans does not exist. We used segmentation of 1.1mm-isotropic 7Tesla T2-weighted- and diffusion-fractional-anisotropy-images to generate and validate an in-vivo probabilistic neuroimaging-based structural atlas of these nuclei in stereotaxic-MNI space. We constructed this atlas to aid the localization of these nuclei in conventional images for future research and clinical investigations of visual/auditory functions.

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