Meeting Banner
Abstract #3262

Cerebrovascular Brain Aging Examined with Arterial Spin Labelling and Applied to Age Prediction

M. Ethan MacDonald1, Nils D. Forkert1, Yuhan Ma2, Rebecca J. Williams1, Alexandru Hanganu1, Hongfu Sun1, Randall Stafford1, Cheryl R. McCreary1, Richard Frayne1, and G. Bruce Pike1

1University of Calgary, Calgary, AB, Canada, 2McGill University, Montreal, QC, Canada

Changes in both cortical thickness and cerebral blood flow are observed with age. In this work, we look at how these parameters are modulated across the lifespan. T1-weighted and arterial spin labelling data from 146 subjects were analyzed, with 68 cortical regions selected in each subject to obtain mean cortical thickness and cerebral blood flow. We calculated rates of change, correlation, and laterality for both parameters. Finally, we explored predictive modeling using cortical thickness, CBF and a model combining the two. Predictive modelling was slightly improved when both measures were included.

This abstract and the presentation materials are available to members only; a login is required.

Join Here