Abstract #3267

Investigation of the default mode network in awake marmosets

Cirong Liu¹, Cecil Chern-Chyi Yen¹, Frank Ye², David Leopold², and Afonso C. Silva¹

¹National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ²National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

We investigated the default mode network (DMN) in awake marmosets, by combining both resting-state and task-based fMRI, and by performing diffusion tractography and neuronal tract tracing. We found that dorsolateral (dlPFC) but NOT medial prefrontal cortex (mPFC) is a major region of the marmoset DMN. The dlPFC has direct anatomical connections and strong functional connectivity with the posterior DMN and also exists in macaques and humans, suggesting that it is more evolutionary conservative than the mPFC. However, its functions as a default mode are poorly understood and worth investigation.

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