Abstract #3288

Normal aging differences in static and dynamic functional connectivity between men and women studied by quantitative data-driven analysis of R-fMRI data

Ninni Persson¹ and Tie-Qiang Li²

¹2Aging Research Center, Karolinska Institute, Stockholm, Sweden, ²Department of Medical Radiation and Nuclear Medicine, Karolinsak University Hospital, Stockholm, Sweden

A growing number of resting-state fMRI (R-fMRI) studies have reported a significant effect of normal aging in resting-state functional connectivity (RFC) of the default mode network (DMN). One of the more intriguing findings is that gender can interact with normal aging effect to influence the RFC changes over lifespan. This adds to our understanding of gender-related cognitive differences and gender-specific nature of aging-related brain disorders. However, the precise interaction effects between sex and age on RFC remain inconclusive. The aim of the study is to quantify the normal aging induced RFC reduction difference between man and women.

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