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Abstract #3327

Dynamic contrast-enhanced and phase contrast MRI of a novel 3D printed cardiac phantom mimicking transmural myocardial perfusion gradients

Xenios Milidonis1, Muhummad Sohaib Nazir1, Myles Capstick2, Sita Drost3, Gertjan Kok4, Nikola Pelevic4, Christian Poelma3, Tobias Schaeffter5, and Amedeo Chiribiri1

1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2ZMT Zurich MedTech AG, Zurich, Switzerland, 3Laboratory for Aero- and Hydrodynamics, Technische Universiteit Delft, Delft, Netherlands, 4VSL B.V., Delft, Netherlands, 5Physikalisch-Technische Bundesanstalt, Berlin, Germany

In recognition of the lack of a physical standard for the assessment and validation of myocardial perfusion imaging methodologies, a phantom simulating first-pass perfusion has recently been developed. This study builds on this work by introducing a novel 3D printed myocardial compartment with a radial variation in flow that mimics physiological transmural perfusion gradients. Velocity and perfusion rate estimates using phase contrast and dynamic contrast-enhanced MRI of the myocardium, respectively, were found to be repeatable. The myocardium shows potential in multi-modality evaluation and validation of perfusion pulse sequences and quantification algorithms before their introduction into routine clinical use.

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