Abstract #3334

Systolic and Diastolic Strain Abnormalities are Observed in Spontaneously Diabetic Non-Human Primates with Diastolic Dysfunction and Preserved Ejection Fraction.

Smita Sampath¹, Li Gong², Yushu Chen³, Chin Han Cheng¹, Zhigang Liang², Stephanie Seah¹, Jie Zheng⁴, Sarayu Parimal¹, Zhu Tong³, Zhang Yu³, Wei Chen³, Asad Abu Bakar Ali¹, Jeffrey L Evelhoch⁵, Wen Zeng², Chih-Liang Chin¹, and Fabao Gao³

¹Translational Biomarkers, MRL, MSD, Singapore, Singapore, ²Sichuan Primed Shines Bio-tech Co. Ltd., Chengdu, China, ³Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, ⁴Department of Radiology, Washington University School of Medicine, St Louis, MO, United States, ⁵Translational Biomarkers, MRL, Merck & Co., Inc., West Point, PA, United States

Non-human primate (NHP) models of cardiovascular disease or metabolic disorder offer a unique framework to evaluate novel therapeutics. Herein, we perform cardiac strain MRI on a 3T MRI scanner to characterize systolic and diastolic function in naïve and spontaneously diabetic NHPs with diastolic dysfunction (T2DM-DD) and preserved ejection fraction (which may represent an early phenotype of HFpEF). In addition, the naïve animals were imaged twice to perform test-retest analysis of the strain-based biomarkers. Peak strains and peak diastolic strain-rates (both circumferential and longitudinal) are significantly impaired in the T2DM-DD monkeys compared to the naïve monkeys indicating impaired systolic and passive diastolic function. In addition, peak untwist rate is also decreased depicting impairment in active diastolic function as well. The test-retest results in the naïve animals show that all biomarkers, with the exception of peak longitudinal strain, are reproducible.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.