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Abstract #3334

Systolic and Diastolic Strain Abnormalities are Observed in Spontaneously Diabetic Non-Human Primates with Diastolic Dysfunction and Preserved Ejection Fraction.

Smita Sampath1, Li Gong2, Yushu Chen3, Chin Han Cheng1, Zhigang Liang2, Stephanie Seah1, Jie Zheng4, Sarayu Parimal1, Zhu Tong3, Zhang Yu3, Wei Chen3, Asad Abu Bakar Ali1, Jeffrey L Evelhoch5, Wen Zeng2, Chih-Liang Chin1, and Fabao Gao3

1Translational Biomarkers, MRL, MSD, Singapore, Singapore, 2Sichuan Primed Shines Bio-tech Co. Ltd., Chengdu, China, 3Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 4Department of Radiology, Washington University School of Medicine, St Louis, MO, United States, 5Translational Biomarkers, MRL, Merck & Co., Inc., West Point, PA, United States

Non-human primate (NHP) models of cardiovascular disease or metabolic disorder offer a unique framework to evaluate novel therapeutics. Herein, we perform cardiac strain MRI on a 3T MRI scanner to characterize systolic and diastolic function in naïve and spontaneously diabetic NHPs with diastolic dysfunction (T2DM-DD) and preserved ejection fraction (which may represent an early phenotype of HFpEF). In addition, the naïve animals were imaged twice to perform test-retest analysis of the strain-based biomarkers. Peak strains and peak diastolic strain-rates (both circumferential and longitudinal) are significantly impaired in the T2DM-DD monkeys compared to the naïve monkeys indicating impaired systolic and passive diastolic function. In addition, peak untwist rate is also decreased depicting impairment in active diastolic function as well. The test-retest results in the naïve animals show that all biomarkers, with the exception of peak longitudinal strain, are reproducible.

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