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Abstract #3360

Multiparametric MRI Reveals Blood-Flow Dependent Spatial and Temporal Variations in Murine Venous Thrombosis

Olivia R Palmer1, Jie Ma2, Jose A Diaz3, and Joan M Greve1

1Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 2Biomedical Engineering and Biostatistics, University of Michigan, Ann Arbor, MI, United States, 3Surgery, Vascular Surgery, University of Michigan, Ann Arbor, MI, United States

There is a critical need for a noninvasive method to determine the optimal treatment for patients with deep vein thrombosis (DVT), the 3rd most common cardiovascular disease. We have implemented multiparametric MRI to evaluate spatial and temporal changes in thrombus composition using two murine models of DVT. We show that T2- and T2*-weighted MRI detects blood-flow dependent variations in thrombus composition. Classification in fully occlusive thrombi indicated an increased inflammatory response and more rapid thrombus organization when compared to thrombi developed in the presence of blood flow. This work provides foundational methodology that could eventually inform optimal DVT treatment planning.

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