Abstract #3406

Accelerated spin-echo fMRI using generalized SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (gSlider-SMS) with 'complex-basis' RF-encoding

SoHyun Han¹, Congyu Liao^1,2, Mary Kate Manhard¹, Berkin Bilgic^1,3, Fuyixue Wang^1,4, Anna I. Blazejewska^1,3, Maaike van den Boomen¹, William A. Grissom⁵, Jonathan R. Polimeni^1,3,6, and Kawin Setsompop^1,3,6

¹Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Department of Biomedical Engineering, Zhejiang Uninversity, Hangzhou, Zhejiang, China, ³Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁴Medical Engineering & Medical Physics, Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States, ⁵Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ⁶Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

High spatiotemporal resolution spin-echo (SE) fMRI acquisition is challenging due to the longer repetition times (TR) compared to conventional gradient-echo (GE) fMRI. In this study, we developed a new method, dubbed ‘complex-basis’ gSlider, which utilizes the spatiotemporal phase-smoothness of SE-fMRI time frames to accelerate the slice coverage of SE-fMRI acquisitions. We further combined ‘complex-basis’ gSlider with conventional SMS to boost the slice-acceleration as well. The proposed method showed comparable tSNR and a two-fold increase in slice-acceleration when compared with standard SE-SMS-EPI. This method would be beneficial for applications requiring high resolution SE-fMRI with whole-brain coverage

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