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Abstract #3406

Accelerated spin-echo fMRI using generalized SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (gSlider-SMS) with 'complex-basis' RF-encoding

SoHyun Han1, Congyu Liao1,2, Mary Kate Manhard1, Berkin Bilgic1,3, Fuyixue Wang1,4, Anna I. Blazejewska1,3, Maaike van den Boomen1, William A. Grissom5, Jonathan R. Polimeni1,3,6, and Kawin Setsompop1,3,6

1Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Department of Biomedical Engineering, Zhejiang Uninversity, Hangzhou, Zhejiang, China, 3Department of Radiology, Harvard Medical School, Boston, MA, United States, 4Medical Engineering & Medical Physics, Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States, 5Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 6Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

High spatiotemporal resolution spin-echo (SE) fMRI acquisition is challenging due to the longer repetition times (TR) compared to conventional gradient-echo (GE) fMRI. In this study, we developed a new method, dubbed ‘complex-basis’ gSlider, which utilizes the spatiotemporal phase-smoothness of SE-fMRI time frames to accelerate the slice coverage of SE-fMRI acquisitions. We further combined ‘complex-basis’ gSlider with conventional SMS to boost the slice-acceleration as well. The proposed method showed comparable tSNR and a two-fold increase in slice-acceleration when compared with standard SE-SMS-EPI. This method would be beneficial for applications requiring high resolution SE-fMRI with whole-brain coverage

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