The aim is to evaluate the reproducibility of intracranial artery feature extraction (iCafe) technique for quantitative analysis of intracranial arteries from 3D time-of-flight (TOF) magnetic resonance angiography (MRA). Twenty-four patients with known intracranial artery stenosis were recruited and underwent two separate MRA scans within 2 weeks. Each dataset was processed blindly using iCafe. Eight morphometry and intensity features were acquired from each artery. The inter-scan reproducibility of iCafe was excellent with intra-class correlation coefficients between 0.92-0.98 and within-subject coefficients of variation between 3.2-8.6% across all features, showing iCafe is a reliable technique for intracranial artery feature quantification from TOF MRA.
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