Abstract #3427

Pipeline for Registering Histological Sections to MRI Volumes

Istvan N. Huszar¹, Karla L. Miller¹, Menuka Pallebage-Gamarallage², Olaf Ansorge², Christopher Mirfin³, Mattias P. Heinrich⁴, and Mark Jenkinson¹

¹Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ³Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ⁴Insitute of Medical Informatics, Universität Lübeck, Lübeck, Germany

Post-mortem MRI–histology comparisons provide great potential to advance our understanding of disease, and validating the source of MRI signals, that is necessary for the development of novel imaging methods to study neurodegeneration. A semi-automated prototype of a registration pipeline is reported, that was designed for conventional sparse histological sampling. Use of the pipeline is demonstrated by inserting individual 25 x 25 mm histological sections to their respective locations in whole-brain MRI data. The registration accuracy is approximately 1 mm.

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