Meeting Banner
Abstract #3461

Investigating the estimated intracranial wall thickness on MRI vessel wall images: what voxel size do we need?

Kees M. van Hespen1, Jaco J.M. Zwanenburg2, Anita A. Harteveld2, Peter R. Luijten2, Jeroen Hendrikse2, and Hugo J. Kuijf3

1Center for Image Sciences, UMC Utrecht, Utrecht, Netherlands, 2Department of Radiology, UMC Utrecht, Utrecht, Netherlands, 3Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands

We investigated the influence of voxel size on the accuracy and precision of intracranial vessel wall thickness measurements on MR images. Circle of Willis specimens were scanned at ultra-high resolution (0.11mm). Downsampling these images showed that distinguishing thin (0.35-0.45mm), medium (0.65-0.75mm) and thick (0.95-1.05mm) vessel walls requires voxel sizes below 0.55-0.66mm, although thickness measurements showed considerable bias at those resolutions. Unbiased measurements required a voxel size of 0.2mm or less. A clinically used MRI protocol (0.8mm), could only correctly measure vessel walls thicker than 0.9mm. In summary, current intracranial vessel wall MRI protocols provide limited quantification of vessel wall thickness.

This abstract and the presentation materials are available to members only; a login is required.

Join Here