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Abstract #3471

Quantification of Wall Shear Stress in the Carotid Arteries of Naïve and Dyslipidemic Non-Human Primates

Smita Sampath1, Weiwei Luo2, Ying-Hua Chu3, Fa-Hsuan Lin3, Michael Klimas4, Elaine Manigbas5, Willy Gsell5,6, Kirsten Jacobsen7, Eric Gifford2, Asad Abu Bakar Ali1, Jeffrey L Evelhoch4, and Chih-Liang Chin1

1Translational Biomarkers, MRL, MSD, Singapore, Singapore, 2Bioinformatics, MRL IT, MSD, Singapore, Singapore, 3National Taiwan University, Taipei, Taiwan, 4Translational Biomarkers, MRL, Merck & Co., Inc., West Point, PA, United States, 5Imaging, Maccine Pte. Ltd., Singapore, Singapore, 6MoSAIC, Biomedical MRI, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium, 7Early Discovery Pharmacology, MRL, MSD, Singapore, Singapore

Herein, we quantified regional carotid wall shear stress (WSS) in 9 naïve NHPs on a normal diet and 4 dyslipidemic NHPs on a high fat diet. A custom-built carotid coil was used to achieve high-resolution imaging. Image analysis was performed including 3D structural and velocity interpolation, contour extraction and through-plane velocity projection. Velocity gradients at the contours were computed to quantify WSS. Animals on high fat diet showed enlarged common carotid arteries (diameter: 2.717 ± 0.195 mm) and lower WSS (0.1478 ± 0.0522 N/m2) compared to animals on a normal diet (diameter: 2.132 ± 0.203 mm, 0.2209 ± 0.0817 N/m2).

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