Abstract #3471

Quantification of Wall Shear Stress in the Carotid Arteries of Naïve and Dyslipidemic Non-Human Primates

Smita Sampath¹, Weiwei Luo², Ying-Hua Chu³, Fa-Hsuan Lin³, Michael Klimas⁴, Elaine Manigbas⁵, Willy Gsell^5,6, Kirsten Jacobsen⁷, Eric Gifford², Asad Abu Bakar Ali¹, Jeffrey L Evelhoch⁴, and Chih-Liang Chin¹

¹Translational Biomarkers, MRL, MSD, Singapore, Singapore, ²Bioinformatics, MRL IT, MSD, Singapore, Singapore, ³National Taiwan University, Taipei, Taiwan, ⁴Translational Biomarkers, MRL, Merck & Co., Inc., West Point, PA, United States, ⁵Imaging, Maccine Pte. Ltd., Singapore, Singapore, ⁶MoSAIC, Biomedical MRI, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium, ⁷Early Discovery Pharmacology, MRL, MSD, Singapore, Singapore

Herein, we quantified regional carotid wall shear stress (WSS) in 9 naïve NHPs on a normal diet and 4 dyslipidemic NHPs on a high fat diet. A custom-built carotid coil was used to achieve high-resolution imaging. Image analysis was performed including 3D structural and velocity interpolation, contour extraction and through-plane velocity projection. Velocity gradients at the contours were computed to quantify WSS. Animals on high fat diet showed enlarged common carotid arteries (diameter: 2.717 ± 0.195 mm) and lower WSS (0.1478 ± 0.0522 N/m2) compared to animals on a normal diet (diameter: 2.132 ± 0.203 mm, 0.2209 ± 0.0817 N/m2).

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