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Abstract #3519

Reconstruction of Accelerated DCE-MRI Guided by Image Quality Metrics

James A Rioux1,2,3, Nathan Murtha4, Chris V Bowen1,2,3,5, Sharon E Clarke1,2,3, and Steven D Beyea1,2,3,5

1Biomedical Translational Imaging Centre, Nova Scotia Health Authority, Halifax, NS, Canada, 2Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, 3Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada, 4Physics, Carleton University, Ottawa, ON, Canada, 5Biomedical Engineering, Dalhousie University, Halifax, NS, Canada

Golden-angle sampling allows arbitrary retrospective selection of temporal resolution in dynamic MRI scans. To select the fastest temporal resolution that preserves time course fidelity, we propose the use of image quality metrics (IQMs). We demonstrate multiple IQMs that correlate strongly with the accuracy of fitted pharmacokinetic parameters up to at least an acceleration factor of R=12. For a fixed undersampling factor, these metrics can also inform the selection of reconstruction parameters such as regularization weights for compressed sensing. This approach may enable rational, individual-level tuning of temporal resolution following a prospectively accelerated DCE-MRI scan.

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