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Abstract #3559

Optimized Single Shot 3D Sequence for High Resolution Hyperpolarized 13C Imaging

Jiazheng Wang1, Richard L Hesketh1, Alan J Wright1, and Kevin M Brindle1,2

1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 2Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

We have developed a single-shot 3D sequence for hyperpolarized 13C MRI, which uses a spatial-spectral (SpSp) pulse for excitation, a train of adiabatic pulses for refocusing, and a stack-of-spirals acquired through a fast-spin-echo train. The sequence achieved an isotropic image resolution of 1.25x1.25x1.25 mm3 in vivo on a 7 T animal system, where hyperpolarized [1-13C]pyruvate and [1-13C]lactate were imaged alternately at a frame rate of 2 s per metabolite. Signals from extra spirals acquired from later spin echoes were averaged with those from the early echoes to give a high signal-to-noise ratio (SNR) as well as high spatial resolution.

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