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Abstract #3563

Mitigating Chemical Exchange Effects in Advanced Pulse Sequences for pH Imaging with Hyperpolarized [13C]bicarbonate

David E Korenchan1, Jeremy W Gordon1, Sukumar Subramaniam1, Renuka Sriram1, Peder E Z Larson1,2, Robert R Flavell1, and John Kurhanewicz1,2

1Radiology and Biomedical Imaging, UC San Francisco, San Francisco, CA, United States, 2Bioengineering, UC San Francisco, San Francisco, CA, United States

Imaging extracellular acidification in tumors will likely lead to better characterization of tumor aggressiveness and treatment efficacy. Hyperpolarized (HP) [13C]bicarbonate magnetic resonance spectroscopic imaging (MRSI) can map pH in murine tumors, but images generally suffer from low signal-to-noise ratio (SNR) and coarse spatial resolution. Although sophisticated pulse sequences can boost SNR, pH accuracy can be compromised due to bidirectional [13C]bicarbonate <-> 13CO2 chemical exchange during imaging. We investigated several pulse sequences and excitation/refocusing schemes, and a modified 2D echo-planar imaging sequence with spectral-spatial excitation demonstrated the best combination of spatial resolution, pH accuracy, and potential for future clinical implementation.

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