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Abstract #3569

Combined FDG-PET and hyperpolarized pyruvate-MRSI (hyperPET) for cancer metabolic phenotyping – a pilot study

Sissel Bisgaard1, Andreas Ettrup Clemmensen1, Abubakr Eldirdiri2, Helle Hjorth Johannesen1, Jan Henrik Ardenkjær-Larsen2, Adam Espe Hansen1, and Andreas Kjær1

1Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark, 2Center for Hyperpolarization in Magnetic Resonance, DTU Elektro, Technical University of Denmark, Kgs. Lyngby, Denmark

Molecular imaging of cancer metabolism in vivo is increasingly employed in clinical settings. Both 18F-FDG PET and hyperpolarized [1-13C]pyruvate MRSI are sensitive to glucose metabolism but differ in which part of the glycolytic pathway is probed. We hypothesize that hyperPET may improve cancer specific metabolic phenotyping. Simultaneous 18F-FDG PET and hyperpolarized [1-13C]pyruvate MRSI (hyperPET) was used in a pilot study, examining the metabolic characteristics exhibited by four different cancer cell lines in nude mice. The results indicated that the combined modalities may distinguish between cancer types.

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