Abstract #3587

The effect of liposomal encapsulation on the chemical exchange properties of diamagnetic CEST agents.

Eleni Demetriou¹, Harriet Story², Robin Bofinger², Helen Hailes², Alethea Tabor², and Xavier Golay³

¹Brain repair and rehabilitation, University College of London, London, United Kingdom, ²Department of Chemistry, University College of London, London, United Kingdom, ³Brain Repair and Rehabilitation, University College of London, London, United Kingdom

Liposome encapsulation of glucose or 2-deoxy-D-glucose (2-DG) may be exploited to enhance the CEST signal by reducing the overall apparent exchange rate. Here we aim to construct a complete theoretical model to measure the exchange properties of diamagnetic CEST agents. Experimentally measured exchange rates of glucose and 2-DG in the liposomal system were found to be reduced by one or two orders of magnitude due to the intermembrane exchange between the intra- and extra-liposomal compartment because of restrictions in water transfer imposed by the lipid membrane. These new theoretical and experimental findings are expected to benefit applications of diamagnetic liposomes to image biological processes.

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