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Abstract #3597

Translating 19F-based cellular MRI from 9.4T to 3T: Feasibility of future clinical applications

Ashley V Makela1,2 and Paula J Foster1,2

1Medical Biophysics, Western University, London, ON, Canada, 2Robarts Research Institute, London, ON, Canada

A limitation of 19F-based MRI is low sensitivity; consequently, many studies have been performed at high field strengths with relatively long scan times (ie. 30 minutes). Because of this, human applications have seemed unreasonable. Here, we investigate the feasibility of translating 19F MRI from 9.4T to a 3T clinical scanner. Upon optimization of 3T scan parameters, 19F image quality was similar and 19F spin quantification was not different to a scan performed at 9.4T. Additionally, a 30 second scan produced the same 19F spin quantification as a 30 minute scan at 3T. These findings show promise for future clinical applications.

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