Abstract #3603

Effect of repetitive head trauma on diffusion MRI derived measures of diffusivity and free water

Virendra R Mishra¹, Zhengshi Yang¹, Karthik Sreenivasan¹, Xiaowei Zhuang¹, Sarah Banks¹, Dietmar Cordes¹, and Charles Bernick¹

¹Imaging, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States

In this study, we utilized the diffusion MRI (dMRI) data of cognitively impaired and nonimpaired active professional fighters from the Professional Fighters Brain Health Study and studied the effect of repeated head trauma on conventional and advanced dMRI derived measures of diffusivity and free-water fraction (fiso). Our study revealed increased fiso and weighted FA in cognitively impaired active fighters, in addition to increased conventional radial and mean diffusivity, which was further associated with years of fighting in impaired fighters. Our study opens new avenues to explore advanced dMRI measures to understand the effect of repetitive head trauma on cognition.

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