Meeting Banner
Abstract #3619

Quantitative Magnetic Resonance Imaging in diabetes: inflammation, oedema and neurodegeneration

Ana-Maria Oros-Peusquens1, Ricardo Loucao1, Elene Iordanishvili1, Melissa Schall1, Markus Zimmermann1, Svenja Caspers2, and N. Jon Shah1

1Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Research Centre Juelich, Juelich, Germany, 2Institute of Neuroscience and Medicine 1, Research Centre Juelich, Juelich, Germany

Type II diabetes is one of the most important metabolic disorders for public health with around 8% prevalence in European population (11% in the US). We report here for the first time a generalized increase in brain water content of ~ 2% in type II diabetics compared to age- and gender-matched controls, supporting the presence of neuroinflammation in diabetes. Several other quantitative measures are investigated (T1, T2*, MT parameters, magnetic susceptibility and diffusion kurtosis) as well as region-based volume, area and cortical thickness. Regions with significant changes in a large number of quantitative parameters are identified.

This abstract and the presentation materials are available to members only; a login is required.

Join Here