Type II diabetes is one of the most important metabolic disorders for public health with around 8% prevalence in European population (11% in the US). We report here for the first time a generalized increase in brain water content of ~ 2% in type II diabetics compared to age- and gender-matched controls, supporting the presence of neuroinflammation in diabetes. Several other quantitative measures are investigated (T1, T2*, MT parameters, magnetic susceptibility and diffusion kurtosis) as well as region-based volume, area and cortical thickness. Regions with significant changes in a large number of quantitative parameters are identified.
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