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Abstract #3628

White Matter Alterations in Parkinson’s Disease Analyzed with Combined Diffusion Magnetic Resonance Imaging and Magnetization Transfer Saturation Imaging: A Tract-Based Spatial Statistics Analysis

Christina Andica1, Koji Kamagata1, Taku Hatano2, Asami Saito1, Yuki Takenaka1,3, Akifumi Hagiwara1,4, Masaaki Hori1, Ryusuke Irie1,4, Akihiko Wada1, Kanako Kumamaru1, Nobutaka Hattori2, and Shigeki Aoki1

1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 4Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Our study combined three in-vivo imaging modalities (diffusion tensor imaging, neurite orientation dispersion and density imaging, and magnetization transfer saturation imaging) to provide a deeper understanding of white matter (WM) pathologies in Parkinson`s disease (PD). The tract-based spatial statistics analysis showed significantly decreased fractional anisotropy and intracellular volume fraction, and increased mean diffusivity, axial diffusivity, and radial diffusivity in an extensive area of WM in PD patients. Meanwhile, non-significantly increased myelin volume fraction was observed in limited areas of WM. The findings of this study might indicate that PD predominantly affects axons rather than myelin in WM.

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