Our study combined three in-vivo imaging modalities (diffusion tensor imaging, neurite orientation dispersion and density imaging, and magnetization transfer saturation imaging) to provide a deeper understanding of white matter (WM) pathologies in Parkinson`s disease (PD). The tract-based spatial statistics analysis showed significantly decreased fractional anisotropy and intracellular volume fraction, and increased mean diffusivity, axial diffusivity, and radial diffusivity in an extensive area of WM in PD patients. Meanwhile, non-significantly increased myelin volume fraction was observed in limited areas of WM. The findings of this study might indicate that PD predominantly affects axons rather than myelin in WM.
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