Abstract #3630

Contribution of basal forebrain damage to cognitive deficits in Parkinson’s disease

Fatma Gargouri^1,2, Cécile Gallea^1,2,3, Marie Mongin^1,2,3, Nadya Pyatigorskaya^1,2,3,4, Romain Valabregue^1,2, Marie Sarazin⁵, Lydia Yahia-Cherif^1,2, Marie Vidailhet^2,3,6, and Stéphane Lehéricy^1,2,3,4

¹Institut du Cerveau et de la Moelle épinière – ICM, Centre de NeuroImagerie de Recherche – CENIR, Paris, France, ²Sorbonne Universités, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, Paris, France, ³ICM Team Control of Normal and Abnormal Movement, Paris, France, ⁴Service de neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France, ⁵Service de Neurologie, Hôpital Saint Anne, Paris, France, ⁶Département de Neurologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France

We investigated the contribution of basal forebrain damage in the cognitive dysfunction of 52 non-demented patients with Parkinson’s disease (PD) and 25 age-matched healthy controls using diffusion and resting state functional MRI. Patients showed diffusion changes in the basal forebrain and the fornix. They also showed reduced functional connectivity between the septal area and the temporal lobe including the hippocampi and parahippocampal gyri, and between the basal nucleus of Meynert and frontal areas and bilateral thalami. Structural and functional changes correlated with memory and executive functions.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.