Parkinson’s disease (PD) is a common progressive neurodegenerative disorder, which affects motor coordination and movement. Currently there is no biomarker for the early diagnosis of disease. In the current study we have evaluated the neurometabolism in rotenone mouse model of PD using 1H-[13C]-NMR NMR spectroscopy in conjunction with an infusion of [1,6-13C2]glucose. Our results show that the neurometabolism is compromised in rotenone treated mice suggesting that both the excitatory and inhibitory neurotransmission are impaired in PD.
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