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Abstract #3651

Relationship between brain and gut in autism spectrum disorder using diffusion MRI and intestinal bacteria gene analysis

Ting-Chun Lin1, Ssu-Ju Li1, Ching-Wen Chang1, Hui-Ching Lin2, Yin-Chieh Liu1, Han-Fang Wu2, Ming-Chia Chu2, You-Yin Chen1, and Yu-Chun Lo3

1Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, Taipei, Taiwan, 2Department and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan, Taipei, Taiwan, 3The PhD Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan, Taipei, Taiwan

Brain-behavior-gut-microbiome interaction, a bidirectional communication, was proposed as an important role in autism spectrum disorders (ASD). However, the correlation among gut microbiota, behavioral performance, and brain microstructure in ASD are remained unclear. We chose a VPA-exposed rat model which performed autistic behaviors to investigate their brain-behavior-gut interaction. Diffusion MRI, behavioral tests, and intestinal bacteria gene analysis were applied in this study. The findings implied that the altered brain microstructure and atypical distribution of the gut microbiota associate with the severity of the autistic behavior in ASD compared to the control group.

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