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Abstract #3656

Mapping the functional and anatomical signatures of chemogenetically modulated neurons in the salience network.

Joanes Grandjean1, Francesca Mandino1, Ling Yun Yeow1, Teoh Chai Lean1, Chris Jun Hui Ho1, Amalina B. E. Attia1, Lai Guan Ng2, Malini Olivo1, Fu Yu1, and Akhila Balachander2

1Singapore Bioimaging Consoritum, Agency for Science, Technology and Research, Singapore, Singapore, 2Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore

BOLD functional magnetic resonance imaging (fMRI) provides crucial information about the large-scale organisation and function of the healthy and diseased brain. Despite its widespread use, identifying the neuronal-basis for specific functional imaging-based signatures, identified in human disorders and animal models, remains a mostly unmet challenge. Presently, we combine chemogenetic neuromodulation with whole-brain resting-state mouse fMRI and tissue clearing, to reveal both the functional contribution and spatial localization of a targeted neuronal population on resting-state functional connectivity. This approach enables researchers to examine the functional role played by selected neuronal populations on distributed neuronal networks.

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