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Abstract #3666

Is occipital bending a structural biomarker of risk for depression and sensitivity to treatment?

Karen Fullard1, Jerome Maller2,3, Thomas Welton3, Matthew Lyon3, Fraser Callaghan3, Leanne Williams4, Mayuresh Korgaonkar5, A. John Rush6, Evian Gordon7, Stephen Koslow8, and Stuart Grieve1,3

1Department of Radiology, Royal Prince Alfred Hospital, Sydney, Australia, 2General Electric Healthcare, Richmond, Australia, 3Sydney Translational Imaging Laboratory, Heart Research Institute, University of Sydney, Sydney, Australia, 4Department of Psychiatry and Behavioural Sciences, Stanford University, Stanford, CA, United States, 5The Brain Dynamics Centre, Westmead Institute for Medical Research, University of Sydney, Sydney, Australia, 6Duke-National University of Singapore, Singapore, Singapore, 7Brain Resource Ltd, Sydney, Australia, 8Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, United States

Occipital Bending (OB) was investigated as an MRI imaging biomarker for major depressive disorder (MDD) using data from large, well characterized, international, randomised study recruiting non-geriatric adult participants (iSPOT-D, n=68 control, 231 MDD). The presence of OB and the angle of occipital bending (OBA) was correlated with a repeated battery of neuropsychiatric assessments, and response to 6 weeks of antidepressant treatment. A greater proportion of rightward bending was present in MDD in comparison to control individuals. Underlying association between OB and MDD is likely.

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