Abstract #3666

Is occipital bending a structural biomarker of risk for depression and sensitivity to treatment?

Karen Fullard¹, Jerome Maller^2,3, Thomas Welton³, Matthew Lyon³, Fraser Callaghan³, Leanne Williams⁴, Mayuresh Korgaonkar⁵, A. John Rush⁶, Evian Gordon⁷, Stephen Koslow⁸, and Stuart Grieve^1,3

¹Department of Radiology, Royal Prince Alfred Hospital, Sydney, Australia, ²General Electric Healthcare, Richmond, Australia, ³Sydney Translational Imaging Laboratory, Heart Research Institute, University of Sydney, Sydney, Australia, ⁴Department of Psychiatry and Behavioural Sciences, Stanford University, Stanford, CA, United States, ⁵The Brain Dynamics Centre, Westmead Institute for Medical Research, University of Sydney, Sydney, Australia, ⁶Duke-National University of Singapore, Singapore, Singapore, ⁷Brain Resource Ltd, Sydney, Australia, ⁸Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, United States

Occipital Bending (OB) was investigated as an MRI imaging biomarker for major depressive disorder (MDD) using data from large, well characterized, international, randomised study recruiting non-geriatric adult participants (iSPOT-D, n=68 control, 231 MDD). The presence of OB and the angle of occipital bending (OBA) was correlated with a repeated battery of neuropsychiatric assessments, and response to 6 weeks of antidepressant treatment. A greater proportion of rightward bending was present in MDD in comparison to control individuals. Underlying association between OB and MDD is likely.

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